Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer.Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.
Professor Tim F. Greten has received his training in Gastroenterology, Hepatology and Medical Oncology. He has been treating patients with hepatocellular carcinoma (HCC) for many years has been leading a number of clinical trials. Apart from his clinical expertise Professor Greten has been interested in the immunological aspects of HCC for more than 20 years. He is conducting basic research studies, which he published in the very top scientific journals including Nature, and Cancer Cell and is also a pioneer in immunotherapy studies in HCC. He published a number of different clinical trials testing different immune based approaches in HCC. Based on this medical and basic science background is considered on the world leaders in tumor immunology and immunotherapy of HCC.
This book is designed to present a practical and evidence-based approach to liver and pancreas surgery that will provide both experienced and novice surgeons as well as surgical trainees a resource for optimizing their outcomes. The entire perioperative spectrum of care is addressed in chapters written by an international panel of experts in the field. Initial sections discuss preoperative assessment and intervention, fluid management, and perioperative pain control. Subsequent chapters focus on the specific aspects of operative approach and technique, including minimally invasive surgery, fluid management, parenchymal transection, and use of drains, tubes and stents. The text concludes with chapters on perioperative pain control, management of complications as well as the role of enhanced recovery pathways. A brief review of the existing literature addressing the particular topic follows in each section. Extensive illustrations, figures, and tables provide reinforcement to the educational content. Optimizing Outcomes for Liver and Pancreas Surgery will provide readers an easy to reference guide with easily accessible text and visual aidstent.
“I have no doubt that this will prove to be a valuable reference text for all clinicians involved in the surgical care of children with disorders of the liver, biliary tract and pancreas, and for hepatobiliary specialists themselves.”
―British Journal of Surgery
“This book will serve as an invaluable resource for gastroenterologists, paediatricians, surgeons, nurses, and others involved in the surgical care of children with liver, biliary, or pancreatic disorders, whether at a specialist children’s centre or a district hospital, and will appeal to trainees, whose exposure these days to complex hepatobiliary surgery is limited. In addition, gastroenterologists and surgeons treating the increasing number of adults with disorders of childhood will find this book a most helpful companion.”
Prof Mark Davenport ChM FRCS (Paeds), Consultant Paediatric Hepatobiliary Surgeon, KCH
Prof Nigel Heaton FRCS, Consultant Transplant Surgeon & Head of Transplantation Programme
Rik Superina, Professor of Pediatric Surgery And Transplantation at Northwestern University’s Feinberg School of Medicine, and Chief of Transplantation at Children’s Memorial Hospital in Chicago.
“It is well written and easy to read. The innovative format that the book applies in which each chapter is entitled by a relevant question, makes it very friendly to the reader and increases its potential to be a quick reference book or companion book for the clinical hepatologist. It is up-to-date, and the use of simple diagrams and tables increase the value of this book. It is a must read for the gastroenterology/hepatology fellow, for the junior Hepatology attending and even for senior hepatologists who would like a quick review of current literature. As the title indicated, it answers typical curbside questions, that often require an extensive search of the literature and deep insight into the hepatology field.”
— Mayra J. Sanchez, MD, Gastroenterology and Hepatology Fellow, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, Journal of Clinical Gastroenterology
“Each question is answered efficiently with appropriate charts and figures. The bridge between medical literature and actual medical practice is a unique aspect to this text. The authors do a great job of separating evidence-based guidelines from expert opinion or personal practice. The overall quality of this text was excellent. Curbside Consultation of the Liver will be a welcome companion for hepatology textbooks and practice guidelines. Physicians, from the resident to the hepatologist, presented with these clinical questions will find this text to be a quick review and adjunct in clinical practice.”
— Geoffrey Fillmore, DO & Mark Jeffries, DO, Scott and White Hospital, Texas A&M Health Science Center, Practical Gastroenterology
“The questions are common and practical; as such the book does an admirable job of meeting the objectives. The chapters are written by the well regarded hepatology faculty from Virginia Commonwealth University Medical Center as well as gastroenterology fellows from this institution. They impact a solid and practical command of the field and are credible authorities. This is a very useful practical approach to commonly encountered hepatology management questions. The format is enjoyable and the information easy to comprehend. It represents a welcome change from the usual staid textbook fare.”
— Willem JS de Villiers, MD, PhD, University of Kentucky College of Medicine, Doody Enterprises, Inc.
“The author provides excellent, practical advice and solutions to 49 of the most frequently asked questions in the management of GERD. This is a user friendly go-to reference for practicing gastroenterologists that is also aimed at residents and GI fellows. This is a very useful addition to a successful series that enhances the practical clinical management of various aspects of GERD. The book provides easily accessible, quick, and direct answers to thorny questions commonly posed among clinical medical and surgical colleagues. It is a welcome breath of fresh air in contrast to the stale mustiness of more conventional textbooks.”
-Willem JS de Villiers, MD, PhD, University of Kentucky College of Medicine, Doody Enterprise, Inc.
“The text is aesthetically pleasing and more importantly, it is small and paperback, thereby making it very portable for students and house staff to carry on rounds or when seeing patients. By asking the very questions that many internists and gastroenterologists encounter daily, Dr. Katz is able to provide us with information not usually found in routine textbooks. Perhaps most impressive is how up-to-date the book is. With many of the references going back only a few years, Dr. Katz gives us recent data in this evolving field. Overall, I feel that this text is an excellent resource for internists, gastroenterologists, and trainees alike. It manages to take many of those challenging clinical scenarios with which we are always faced, and in one easy-to-read book, gives a rational approach to each.”
— Amar R. Deshpande, MD, Assistant Professor of Medicine, Division of Gastroenterology, University of Miami, Miller School of Medicine, Practical Gastroenterology
“…Dr. Katz provides very clear, easy-to-follow, and evidence-based answers to each question. He does not shy away from tough clinical questions that occasionally do not have simple or straightforward answers. He attempts to weight all possible options while at the same time offering a clear diagnostic and/or therapeutic approach…The simple arrangement of the content, in a question-answer format, makes the book very attractive for a busy gastroenterologist and potentially other health care personnel who work in the GI field, such as surgeons, nurse practitioners, physician assistants and even primary care physicians…Bottom Line: This is an excellent book that is likely to be utilized daily. Its small size makes it easy to carry. This new book style represents a refreshing attempt to make medical textbooks more user friendly and part of the doctor’s daily source of medical information.”
— Ronnie Fass, Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, and University of Arizona, Tucson, AR, Gastroenterology
Philip O. Katz, MD, FACG is Chairman of the Division of Gastroenterology at Albert Einstein Medical Center and Clinical Professor of Medicine at Jefferson Medical College in Philadelphia, PA. He is also Associate Program Director of the Department of Medicine at Albert Einstein Medical Center.
Dr. Katz received his medical degree from the Bowman Gray School of Medicine at Wake Forest University in Winston-Salem, NC. He served his residency and chief residency in internal medicine, followed by a fellowship in gastroenterology at the Bowman Gray School of Medicine. He completed a faculty development fellowship at Johns Hopkins University in Baltimore, MD. He is board certified in internal medicine and gastroenterology.
Dr. Katz is currently Vice President of the American College of Gastroenterology and is a member of the American Gastroenterological Association and the American Society for Gastrointestinal Endoscopy.
A recognized national authority on esophageal disease, Dr. Katz’s research interests include all aspects of gastroesophageal reflux disease, including nocturnal recovery of gastric acid secretion during proton pump inhibitor therapy and esophageal pain perception. Dr. Katz is a practicing clinician with active teaching and editorial positions. In addition to lecturing on many gastroenterology-related topics, Dr. Katz is Associate Editor for Reviews in Gastrointestinal Disorders (Med Reviews) and an editorial reviewer for Annals of Internal Medicine, American Journal of Gastroenterology, Gastroenterology, and Digestive Diseases and Sciences. He has contributed to the publication of over 120 peer-reviewed papers as well as numerous abstracts, books, book chapters, and monographs.
Written by many of the world’s leading colorectal surgeons, this evidence-based text investigates the risks and benefits of colorectal surgeries. By using clinical pathways, algorithms, and case discussions, the authors identify the best practices for patient safety and positive outcomes to ensure that physicians correctly recognize potential problems and carefully manage complications.
Improved Outcomes in Colon and Rectal Surgery is a must read and essential reference for all colorectal surgeons, fellows and residents, as well as those working in gastroenterology and the medico-legal profession.
This book starts with a description of the anatomy of the umbilicus and its ideal shape. After a brief summary of the history of umbilical reconstruction, currently used umbilical reconstructive techniques are presented. The reader will also find information on the reconstruction of the umbilicus after malignant melanoma; outcomes and complications will be discussed in the last chapters. Written by respected authors, this book will offer residents and fellows as well as practicing and highly experienced plastic surgeons essential guidance on treatment and decision-making concerning umbilical reconstruction. Its numerous illustrations and clearly structured content make the book a must-read.
Melvin A. Shiffman, MD, JD, FCLM, received his MD from Northwestern University School of Medicine in 1957 and completed his residency in general surgery in 1964 at the Veterans Administration Hospital, Long Beach, California. Since then he has been continuously involved in the practice of oncologic surgery, reconstruction, and cosmetic surgery. In 2002, Dr. Shiffman became Chair of the Section of Surgery at Tustin Hospital and Medical Center and in 2009-10 he served as President of the American College of Legal Medicine. He is Editor Emeritus of the American Journal of Cosmetic Surgery, a member of the Scientific Committee of the American Journal of Aesthetic Medicine, and an examiner for the International Board of Cosmetic Surgery. He is also a former Editor-in-Chief of both the American Journal of Cosmetic Surgery and the International Journal of Cosmetic Surgery. Dr. Shiffman is the recipient of many honors and is a Fellow of various colleges and societies. He has published almost 300 articles, authored or edited 34 books, and written more than 140 book chapters.
A Diagnostic Atlas of Tumors of the Upper Aero-Digestive Tract brings readers up to date on the correct identification and diagnosis of malignancies of the larynx, pharynx, and esophagus. The atlas provides broad-based coverage of these anatomical areas and highlights the different pathologies physicians may encounter.
Key features of this illustrated guide include: A thorough exploration of the entire upper aero-digestive tract and its pathologies Recent advances in flexible endoscopy, which makes visualization, identification, biopsy, and treatment of conditions of the upper aero-digestive tract easier and possible under local anesthesia in an outpatient setting More than 170 high-quality images Accompanying video clips of the technology available online
Accessible and concise, the book is suitable for a range of readers, including: Oncologists, Otolaryngologists, Gastroenterologists, Respiratory and ENT physicians, Maxillo-facial, thoracic, and upper gastrointestinal surgeons, medical students, nurses, and medical trainees.
A number of areas within liver transplant continue to evolve as the field matures. The advent of increasingly effective therapy for HCV will dramatically reduce the burden of recurrent disease within the next few years. HCC has become a well established indication for transplant with an increasing emphasis on adjuvant therapies to reduce the risk of tumor recurrence and potentially expand the acceptable limits of tumor burden amenable to liver transplant. Renal dysfunction is a frequent complication of decompensated liver disease and an important predictor of diminished post-transplant survival. Newer approached to therapy including terlipressin will reduce the impact of renal dysfunction in liver transplant candidates and potentially reduce the need for combined liver/kidney transplant. Increasing attention is being paid to role of comorbidities such as diabetes and hypertension on longterm recipient outcomes. Retransplantation remains a challenge with a variety of models available ot redict outcomes. Cardiac disease pretransplant is an area of active investigation with newer entities such as cirrhotic cardiomyopathy a growing concern. These are some of many evolving issues in liver transplant which will be addressed to update our readers and which in turn will enhance the care of patients with liver disease.