Adult T-cell Leukemia/Lymphoma 1st ed. 2017 Edition

This book provides essential information on the epidemiology, molecular and genetic features, anti-CCR4 antibody therapy and a nationwide study of transplantation on human T-leukemia virus type-I (HTLV-1) and adult T-cell leukemia/lymphoma (ATL). This rare but important disease has restricted endemic areas and distinct clinical features such as a high frequency of hypercalcemia, strong predisposition to infection and poor response to chemotherapy, aspects which set ATL apart from other types of non-Hodgkin lymphoma. Given the small number of patients, enrollment in clinical trials has not been feasible, and establishing treatment standard has been difficult but new evidence, such as results of nationwide studies on transplantation, have shown new insights and potential treatments. Based on recent evidence, the book presents new treatment methods for ATL and infection prevention of HTLV-1, enabling clinicians, researchers and post-docs specializing in hematology and virology to gain a valuable overview of the disease.

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Cancer Epidemiology: Volume 1, Host Susceptibility Factors (Methods in Molecular Biology) (v. 1) 2009th Edition

Population studies and epidemiology facilitate the discovery of genetic and environmental determinants of cancer and the development of new approaches to cancer control and prevention, therefore they play a central role in the creation of health policies. Cancer Epidemiology compiles areas of research which cover etiological factors or determinants that contribute to the development of cancer and describe the latest technologies in cancer epidemiology. In Volume 1, Host Susceptibility Factors, leading experts provide chapters on cancer incidence, prevalence, mortality and surveillance, methods, technologies and study design in cancer epidemiology as well as host susceptibility factors in cancer epidemiology. Although a non-standard volume of the highly successful Methods in Molecular Biology™ series, this comprehensive text retains the commitment of the series to collecting the kind of detailed, up-to-date information and implementation advice that is crucial for getting optimal results.

Cutting-edge and essential, Cancer Epidemiology allows readers to get the maximum advantage of the methods involved in this exciting and important field.

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Seven Modern Plagues: and How We Are Causing Them 2nd Edition

Epidemiologists are braced for the big one: the strain of flu that rivals the pandemic of 1918-1919, which killed at least 20 million people worldwide. In recent years, we have experienced scares with a host of new influenza viruses: bird flu, swine flu, Spanish flu, Hong Kong flu, H5N1, and most recently, H5N7. While these diseases appear to emerge from thin air, in fact, human activity is driving them. And the problem is not just flu, but a series of rapidly evolving and dangerous modern plagues.
According to veterinarian and journalist Mark Walters, we are contributing to-if not overtly causing-some of the scariest epidemics of our time. Through human stories and cutting-edge science, Walters explores the origins of seven diseases: mad cow disease, HIV/AIDS, Salmonella DT104, Lyme disease, hantavirus, West Nile, and new strains of flu. He shows that they originate from manipulation of the environment, from emitting carbon and clear-cutting forests to feeding naturally herbivorous cows “recycled animal protein.”

Since Walters first drew attention to these “ecodemics” in 2003 with the publication of Six Modern Plagues, much has been learned about how they developed. In this new, fully updated edition, the author presents research that precisely pinpoints the origins of HIV, confirms the link between forest fragmentation and increased risk of Lyme disease, and expands knowledge of the ecology of West Nile virus.

He also explores developments in emerging diseases, including a new chapter on flu, examining the first influenza pandemic since the Hong Kong flu of 1968; a new tick-borne infection in the Mid-West; a second novel bird flu in China; and yet a new SARS-like virus in the Middle East.

Readers will not only learn how these diseases emerged but the conditions that make future pandemics more likely. This knowledge is critical in order to prevent the next modern plague.

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Primary Sclerosing Cholangitis: Current Understanding, Management, and Future Developments 1st ed. 2017 Edition

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This text provides a state-of-the art review of primary sclerosing cholangitis (PSC). The volume focuses on new data about risk factors for PSC, its natural history of the disease, and the epidemiology and genetics of PSC, while providing a comprehensive overview on current and future therapies for PSC, management of cholangiocarcinoma, and other hepatobiliary malignancies. It also touches upon up-to-date surgical and endoscopic management, including liver transplantation- both deceased donor and living related liver transplantation.
Written by experts in the field, Primary Sclerosing Cholangitis: Current Understanding, Management, and Future Developments is a valuable resource for clinicians, surgeons and researchers with an interest in biliary liver disease, inflammatory bowel disease, and liver transplantation.
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World Atlas of Epidemic Diseases (Arnold Publication)

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The euphoria about the defeat of epidemics which surrounded the global eradication of smallpox in the 1970s proved short-lived. The advent of AIDS in the following decade, the widening spectrum of other newly-emergent diseases (from Ebola to Hanta virus), and the resurgence of old diseases such as tuberculosis and malaria all suggest that the threat of epidemic diseases remains at an historic high. The World Atlas of Epidemic Diseases provides a timely and scholarly review of over fifty of the most important such diseases at the start of the twenty-first century.

This stunningly presented collection of maps, illustrations and commentary offers an authoritative overview of the global distribution of major epidemic diseases on a variety of spatial scales from the local to the global. The Atlas is arranged in an historical sequence, beginning with classic plagues such as the ‘Black Death’ and cholera and moving on through smallpox and measles to ‘modern’ diseases such as AIDS and Legionnaires’ disease. Over 400 figures are incorporated, including 150 specially drawn maps supported by micrographs of the causative agents, photographs of the disease vectors, historical prints and graphs of changing incidence. The text for each disease includes discussion of its nature and epidemiological features, its origin (where known) and historical impacts, and its global status at the start of the twenty-first century. The book concludes with an informed look towards the future, assessing the probable impacts of major medical advances on life expectancy and the chances of success of programmes for the global eradication of diseases such as polio and measles.

The World Atlas of Epidemic Diseases makes a major new contribution to our knowledge of the global burden of disease and is an informative and fascinating reference on the changing distributions of disease. It will be an invaluable resource for anyone interested in the spread, control and eradication of epidemic disease.

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Emerging Infectious Diseases: A Guide to Diseases, Causative Agents, and Surveillance (Public Health/Epidemiology and Biostatistics

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This important resource offers a comprehensive introduction to emerging and reemerging infectious disease, including the underlying mechanisms of microbial emergence, the technology used to detect them and the strategies available to contain them. The author describes the diseases and their causative agents that are major factors in the health of populations the world over. One of the main features of the book is its broad coverage of 25 different emerging infectious diseases, most of which are directly important to those practicing health in the U.S. The book is designed for students in epidemiology, global health, and biology.

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The Essentials of Biostatistics for Physicians, Nurses, and Clinicians Paperback – 19 Aug 2011

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Designed specifically for healthcare practitioners who need to understand basic biostatistics but do not have much time to spare, The Essentials of Biostatistics for Physicians, Nurses and Clinicians presents important statistical methods used in today′s biomedical research and provides insight on their appropriate application. Rather than provide detailed mathematics for each of these methods, the book emphasizes what healthcare practitioners need to know to interpret and incorporate the latest biomedical research into their practices.

The author draws from his own experience developing and teaching biostatistics courses for physicians and nurses, offering a presentation that is non–technical and accessible. The book begins with a basic introduction to the relationship between biostatistics and medical research, asking the question “why study statistics?,” while also exploring the significance of statisitcal methods in medical literature and clinical trials research. Subsequent chapters explore key topics, including:

  • Correlation, regression, and logistic regression
  • Diagnostics
  • Estimating means and proportions
  • Normal distribution and the central limit theorem
  • Sampling from populations
  • Contingency tables
  • Meta–analysis
  • Nonparametric methods
  • Survival analysis

Throughout the book, statistical methods that are often utilized in biomedical research are outlined, including repeated measures analysis of variance, hazard ratios, contingency tables, log rank tests, bioequivalence, cross–over designs, selection bias, and group sequential methods. Exercise sets at the end of each chapter allow readers to test their comprehension of the presented concepts and techniques.

The Essentials of Biostatistics for Physicians, Nurses, and Clinicians is an excellent reference for doctors, nurses, and other practicing clinicians in the fields of medicine, public health, pharmacy, and the life sciences who need to understand and apply statistical methods in their everyday work. It also serves as a suitable supplement for courses on biostatistics at the upper–undergraduate and graduate levels.

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Modern Epidemiology Third Edition

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The thoroughly revised and updated Third Edition of the acclaimed Modern Epidemiology reflects both the conceptual development of this evolving science and the increasingly focal role that epidemiology plays in dealing with public health and medical problems. Coauthored by three leading epidemiologists, with contributions from sixteen experts in a variety of epidemiologic sub-disciplines, this new edition is by far the most comprehensive and cohesive text on the principles and methods of epidemiologic research. The book covers a broad range of concepts and methods, including epidemiologic measures of occurrence and effect, study designs, validity, precision, statistical interference, and causal diagrams. Topics in data analysis range from Bayesian analysis, sensitivity analysis, and bias analysis, with an extensive overview of modern regression methods including logistic and survival regression, splines, hierarchical (multilevel) regression, propsensity scores and other scoring methods, and g-estimation. Special-topics chapters cover disease surveillance, ecologic studies, social epidemiology, infectious disease epidemiology, genetic and molecular epidemiology, nutritional epidemiology, environmental epidemiology, reproductive epidemiology, clinical epidemiology, and meta-analysis.

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Forensic Epidemiology: Principles and Practice 1st Edition

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It is an inescapable fact that causation, both generally (in populations), and specifically (in individuals), cannot be observed. Rather, causation is determined when it can be inferred that the risk of an observed injury or disease from a plausible cause is greater than the risk from other plausible causes. While many causal evaluations performed in forensic medicine are simplified by the fact that the circumstances surrounding the onset of an injury or disease clearly rules out competing causes (eg, a death following a fall), there are many cases that present a more complicated picture. It is these types of investigations, in which an analysis of comparative levels of risk from competing causes is needed to arrive at a reliable and accurate determination of the most likely cause, that forensic epidemiology (FE) is directed at.
In Forensic Epidemiology, the authors present the legal and scientific theories underlying the methods by which risk is used in the investigation of individual causation. Methods and principles from epidemiology are combined with those from a multitude of other disciplines, including general medicine, pharmacology, forensic pathology, biostatistics, and biomechanics, inter alia, as a basis for investigating the plausibility of injury and disease exposures and mechanisms. The ultimate determination of the probability of causation (PC) results from an assessment of the strength of association of the investigated relationship in the individual, based on a comparison between the risk of disease or injury from the investigated exposure versus the risk of the same disease or injury occurring at the same point in time in the individual, but absent the exposure. The principles and methods described in Forensic Epidemiology will be of interest to those who work and study in the fields of forensic medicine, epidemiology, and the law.

  • Historical perspective on how epidemiologic evidence of causation has been used in courts in the US and Europe
  • Theory and science underlying the use of risk to assess individual causation
  • Primer on epidemiologic methods, and various measures used to arrive at individualized comparative risk assessments and PC
  • The use of statistical methods applied to publicly available data for ad hoc analysis of PC applicable to the specific circumstances of a case
  • Background on complementary disciplines, including forensic pathology, death investigation, biomechanics, and survival analysis
  • Examples of applied FE in the investigation of traffic injury and death, automotive and other product defect litigation, medical negligence, and criminal prosecution and defense

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